disparities

Ancestral characterization of 1018 cancer cell lines highlights disparities and reveals gene expression and mutational differences

Although cell lines are an essential resource for studying cancer biology, many are of unknown ancestral origin, and their use may not be optimal for evaluating the biology of all patient populations. An admixture analysis was performed using …

Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

To characterize the extent and impact of ancestry-related biases in precision genomic medicine, we use 642 whole-genome sequences from the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) project to evaluate typical …